Staphylococcus aureus Xen36 strain生物发光金黄色葡萄球菌菌株

Infectious disease is a perennially important area for both life science research and drug discovery. Some of the first applications of IVIS? imaging technology were in tracking infections and monitoring host responses, and these applications are still at the forefront of research. PerkinElmer's bioluminescent infectious disease light-producing microorganisms have been developed to mimic both acute and chronic standard infection protocols presently used by researchers.Engineered Bacterium: Staphylococcus aureus - Xen36Parental Strain: American Type Culture Collection, used under licenseIn Vitro/Ex Vivo: Growth, Biochemical, and Antibiogram profiles, Catheter modelIn Vivo: Biofilm Advantages of using bioluminescent light-producing microorganisms for drug discovery in vitro:Rapid and readily amenable to high throughput screening, e.g., 96 or 384-well formatSensitivity - subtle changes in cellular viability are rapidly detectedInexpensive - no additional substrates needed for bacterial assays Advantages of using bioluminescent light-producing microorganisms for drug discovery in vivo:Rapid identification of lead drug candidatesReal-time efficacy dataMay help to decrease drug failure by allowing disease relapse to be monitored in the same animal

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